2012

Urbé,S., Liu,H., Hayes,S.D., Heride,C., Rigden,D.J. and Clague,M.J. (2012) Systematic survey of deubiquitinase localisation identifies USP21 as a regulator of centrosome and microtubule associated functions. Mol. Biol. Cell in press [abstract].

Liu,H., Urbé,S. and Clague,M.J. (2012) Selective protein degradation in cell signaling. Seminars in Cell and Developmental Biology in press [abstract].

Clague,M.J., Coulson,J.M. and Urbé,S. (2012) Cellular functions of the DUBs. J. Cell Sci. in press.

2011

Elliot,P.R., Liu,H., Pastok,M.Y., Grossman,G.J., Rigden,D., Clague,M.J., Urbé,S. and Barsukov, I. (2011) Structural variability of the Ubiquitin Specific Protease DUSP-UBL double domains. FEBS Lett. 585, 3385-3390 [abstract].

Clague,M.J. (2011) Met receptor: a moving target Science Signaling 4, pe40 [abstract].

Thorne, C.T., Eccles, R.L., Coulson,J.M., Urbé,S. and Clague,M.J. (2011) Isoform specific localisation of the deubiquitinase USP33 to the Golgi apparatus, Traffic 12, 1563-1574 [abstract].

2010

Clague,M.J. and Urbé,S. (2010) Ubiquitin: same molecule, different degradation pathways. Cell, 143, 682-685 [abstract]

Polson, H.E.J., De Lartigue,J., Rigden,D.J., Reedijk,M., Urbé,S., Clague,M.J., Tooze,S.A. (2010) Mammalian Atg18 (WIPI2) localises to omegasome-anchored isolation membranes and positively regulates LC3 lipidation Autophagy, 4, 506-522 [abstract].

Hammond,D.E., Hyde, R., Kratchmarova,I., Beynon,R.J., Blagoev,B. and Clague,M.J. (2010) Quantitative analysis of HGF and EGF-dependent phosphotyrosine signalling networks. Journal of Proteome Research 7, 2734-2742 [abstract].

Omerovic, J., Clague,M.J. and Prior,I.A. (2010) Phosphatome profiling reveals PTPN2, PTPRJ and PTEN as negative regulators of PKB/Akt activation in Ras mutated cancer cells. Biochem J. 426, 65-72 [abstract]

Sacco, J.J., Coulson,J.M., Clague,M.J. and Urbé,S. (2010) Emerging roles of deubiquitinases in cancer-associated pathways. IUBMB Life, 62, 150-157 [abstract].

2009

Buus, R., Faronato,M., Hammond, D.E., Urbé,S. and Clague M.J. (2009) Deubiquitinase activities required for Hepatocyte Growth Factor-induced scattering of epithelial cells Current Biology 19, 1463-1466 [article]

Komander, D.,Clague,M.J. and Urbé,S. (2009) Breaking the chains: structure and function of the deubiquitinases. Nature Reviews of Molecular Cell Biology 10, 550-563 [article].

Liu, H., Buus, R. Clague, M.J. and Urbé, S. (2009) Regulation of ErbB2 status by the proteasomal DUB POH1. PLOS One, 4 (5): e5544 [article].

De Lartigue, J., Polson,H., Feldman, M., Shokat, K., Tooze, S.A., Urbé, S. and Clague, M.J. (2009) PIKfyve regulation of endosome-linked pathways. Traffic, 10, 883-893 [article].

Rigden,D.J., Liu, H., Hayes,S.D., Urbé, S. and Clague, M.J. (2009) Ab initio protein modelling reveals novel human MIT domains. FEBS Lett. 583, 872-878 [article].

Clague,M.J.,Urbé, S. and De Lartigue,J. (2009) Phosphoinositides and the endocytic pathway. Experimental Cell Research, 9, 1627-1631. [article]

Doherty, M.K, Hammond, D.E., Clague,M.J., Gaskell, S.J. and Beynon, R.J. (2009) Turnover of the human proteome: determination of intracellular protein stability by dynamic SILAC. Journal of Proteome Research 8, 104-112 [article].

2008

Clague,M.J. and Urbé, S. (2008) Quick guide: Multivesicular bodies Current Biology 18, R402-R404 [article]

Clague, M.J. Coulson,J.M. and Urbé, S. (2008) Deciphering histone H2A deubiquitination. Genome Biology 9, 202 [article]

Omerovic, J., Hammond, D.E., Clague,M.J. and Prior, I.A. (2008) Ras isoform abundance and signalling in human cancer cell lines. Oncogene,27, 2754-2762 [article].

2007.

Row,PE, Liu,H,, Hayes,S. Welchman,R., Charalabous,P., Hofmann,K., Clague,MJ., Sanderson,CM. and Urbé,S. (2007)The MIT domain of UBPY constitutes a CHMP binding and endosomal localisation signal required for efficient EGF receptor degradation. J. Biol. Chem.282, 30929-37 [abstract].

Ross SH, Lindsay Y, Safrany ST, Lorenzo O, Villa F, Toth R, Clague MJ, Downes CP, Leslie NR. (2007) Differential redox regulation within the PTP superfamily. Cell Signal.19, 1521-30.

2006

Clague, M.J and Urbé, S. (2006) Endocytosis: the DUB version. Trends in Cell Biology 16, 551-559 [abstract]

Lorenzo, O., Urbé,S. and Clague,M.J. (2006) Systematic analysis of myotubularins: heteromeric interactions, subcellular localisation and endosome related functions. J. Cell Sci. 119, 2953-2959 [abstract].

Hammond, D.E. and Clague,M.J. (2006) Membrane Traffic: Catching the lysosome express. Current Biology, 16, R416-R418 [abstract].

Row P.E., Prior,I.A., McCullough J., Clague M.J., Urbé S. (2006) The ubiquitin isopeptidase UBPY regulates endosomal ubiquitin dynamics and is essential for receptor down-regulation. J. Biol. Chem. 281, 12618-12624 [abstract].

McCullough J., Row P.E., Lorenzo, O. Doherty M., Beynon R., Clague M.J., Urbé S. (2006) Activation of the endosome associated deubiquitinating enzyme AMSH by STAM, a component of the multivesicular body pathway.Current Biology, 16, 160-165 [abstract].

2005

Clague,M.J. and Lorenzo,O. (2005) The myotubularin family of lipid phosphatases. Traffic 6, 1033-1069 [abstract].

Row,P.E., Clague,M.J. and Urbé,S. (2005) Growth factors induce differential phosphorylation profiles of the Hrs-STAM complex: a common node in signalling networks with signal-specific properties.Biochem. J. 389, 629-636 [article].

Lorenzo,O., Urbé,S. and Clague,M.J. (2005) Analysis of phosphoinositide binding domain function in myotubularin related protein 3, MTMR3. J. Cell Sci. 118, 2005-2012 [abstract].

2004

Carter,S., Urbé,S. and Clague,M.J. (2004) The Met receptor degradation pathway: requirement for K48-linked polyubiquitin independent of proteasome activity. J. Biol. Chem. 51, 52835-52839 [abstract].

McCullough,J., Clague,M.J. and Urbé,S. (2004) AMSH: an endosome associated ubiquitin isopeptidase. J. Cell Biol. 166, 487-492 [abstract].

Hammond,D.E., Carter,S. and Clague,M.J. (2004) Met receptor dynamics and signalling. Current Topics in Microbiology and Immunology 286, 21-44.

Clague,M.J., Dove.S.K. and Barr,F.A. (2004) I-proteins: a proposed switch in myotubularin function. Trends in Biochemical Sciences 29,58-61 [abstract].

2003

Clague,M.J. and Urbé,S. (2003) Hrs function: viruses provide the clue. Trends in Cell Biology 13, 603-606 [abstract].

Urbé,S., Sachse,M., Row,P.E., Preisinger,C., Barr,F.A., Strous,G., Klumperman,J. and Clague,M.J. (2003) The UIM domain of Hrs couples receptor sorting to vesicle formation. J. Cell Sci. 116, 4169-4179 [abstract].

Hammond,D.E. Carter,S., McCullough,J. Urbé,S, Vande Woude,G. and Clague,M.J. (2003) Endosomal dynamics determine Met signalling. Mol. Biol. Cell 14, 1346-1354 [abstract].

Schaletzky,J., Dove,S.K., Short,B., Lorenzo,O., Clague,M.J. and Barr,F.A. (2003) Phosphatidylinositol-5-phosphate activation and conserved substrate specificity of the myotubularin family of phosphatidylinositol 3-phosphatases Current Biology 13, 504-509 [article].

Blumenthal,R. Clague,M.J., Durrell, S.R. and Epand,R.M. (2003) Membrane fusion. Chemical Reviews 103, 53-70 [article].

2002

Clague,M.J. (2002) Membrane transport: A coat for ubiquitin. Current Biology, 12, R529-R531 [article].

2001

Walker,D.M., Urbé,S., Dove,S.K., Tenza,D., Raposo,G. and Clague,M.J. (2001) Characterization of MTMR3: an inositol lipid 3-phosphatase with novel substrate specificity. Current Biology 11, 1600-1605. [abstract]

Clague,M.J. and Urbé,S. (2001) The interface of receptor trafficking and signaling, J. Cell Sci.,114, 3075-3081. [abstract]

Hammond,D.E., Urbé,S., Vande Woude,G.F. and Clague,M.J. (2001) Down-regulation of Met, the receptor for hepatocyte growth factor. Oncogene, 20, 2761-2770.[abstract]

Mills,I.G., Urbé,S. and Clague,M.J. (2001) Relationships between EEA1 binding partners and their role in endosome fusion. J. Cell Sci., 114, 1959-1965 [full article PDF]

2000

Clague,M.J. and Herrmann,A. (2000) Membrane transport: deciphering fusion. Current Biology, 10, R750-752. [abstract] [full article PDF].

Urbé,S., Mills,I.G., Stenmark,H., Kitamura,N. and Clague,M.J. (2000) Endosomal localisation and receptor dynamics determine tyrosine phosphorylation of Hrs. Molecular and Cellular Biology, 20, 7685-7692.[abstract] [full article PDF]

Earlier Stuff

Prior IA, Clague MJ.(1999) Localization of a class II phosphatidylinositol 3-kinase, PI3KC2a, to clathrin-coated vesicles . Mol Cell Biol Res Commun. 1, 162-166. [full article pdf]

Clague,M.J. (1999) Membrane transport: take your fusion partners. Current Biology, 9, R258-260 [abstract]

Clague, M.J. (1998) Molecular aspects of the endocytic pathway. Biochem. J. 336, 271-282 [full text]

Mills,I.G., Jones,A.T. and Clague,M.J. (1998) Involvement of the endosomal autoantigen EEA1 in homotypic fusion of early endosomes. Current Biology, 8, 881-884. [abstract]

Jones,A.T., Mills,I.G., Scheidig,A.J., Alexandrov,K. and Clague,M.J. (1998) Inhibition of endosome fusion by wortmannin persists in the presence of activated rab5. Mol. Biol. Cell 9, 323-332. [full text]

Nüßler,F., Clague,M.J., Herrmann,A. (1997) Meta-stability of the hemifusion intermediate induced by glycosylphosphatidylinositol-anchored influenza hemagglutinin. Biophys. J. 73, 2280-2291 [abstract]

Gaffet,P., Jones,A.T. and Clague,M.J. (1997) Inhibition of cation-independent mannose 6-phosphate receptor incorporation into trans-Golgi network-derived clathrin-coated vesicles by wortmannin. J. Biol. Chem. 272, 24170-24175 [abstract]

Prior, I.A. & Clague,M.J. (1997) Glutamate uptake occurs at an early stage of synaptic vesicle recycling. Current Biology 7, 353-356 [abstract]

Jones,A.T. and Clague,M.J. (1995) Phosphatidylinositol 3-kinase activity is required for early endosome fusion. Biochem J. 311, 31-34. [abstract]

Clague,M.J., Thorpe,C. & Jones,A.T. (1995) Phosphatidylinositol 3-kinase regulation of fluid phase endocytosis FEBS Lett. 367, 272-274.

Clague,M.J., Urbé,S., Aniento,F., & Gruenberg.J. (1994). Vacuolar-ATPase activity is required for endosomal carrier vesicle formation. J.Biol.Chem. 269, 21-24. [pdf]