Cell Signalling Laboratory

 
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PUBLICATIONS

pdfs available upon request

2011
* Prior IA and Hancock JF. Ras trafficking, localization and compartmentalized signalling. Semin. Cell Dev. Biol. (2011) in press
* Eisenberg S, Beckett AJ, Prior IA, Dekker FJ, Hedberg C, Waldmann H, Ehrlich M and Henis YI. Mol. Cell Biol. (2011) 31: 3938-52
* Cheeseman LP, Booth DG, Hood FE, Prior IA and Royle SJ. Aurora A kinase activity is required for localization of TACC3/ch-TOG/clathrin intermicrotubule bridges. Commun. Integr. Biol. (2011) 4: 409-12
* Booth DG, Hood FE, Prior IA and Royle SJ. A TACC3/ch-TOG/clathrin complex stabilzes kinetochore fibres by inter-microtubule bridging. EMBO J. (2011) 30: 906-919
* Rodriguez-Lorenzo L, Krpetic Z, Barbosa S, Alvarez-Puebla RA, Liz-Marzán LM, Prior IA and Brust M. Intracellular mapping with SERS-encoded gold nanostars. Integr. Biol. (2011) 3: 922-6
* Krpetic Z, Nativo P, Prior IA and Brust M. Acrylate facilitated celular uptake of gold nanoparticles. Small (2011) 7: 1982-6
* Krpetic Z, Saleemi S, Prior IA, Sée V, Qureshi R and Brust M. Negotiation of intracellular barriers by TAT-modified gold nanoparticles. ACS Nano (2011) 5: 5195-5201
* Meng X, Seton H, Lu LT, Prior IA, Thanh NTK and Song B. Magnetic CoPt nanoparticles as MRI contrast agents for transplanted neural stem cells detection. Nanoscale (2011) 3: 977-84.

2010
* Krpetic Z, Nativo P, Sée V, Prior IA, Brust M and Volk M. Inflicting controlled nonthermal damage to subcellular structures by laser-activated gold nanoparticles. Nano Letters (2010) 10: 4549-54
* Wilson R, Spiller DG, Beckett A, Prior IA and Sée V. Highly stable dextran-coated Quantum Dots for biomolecular detectin and cellular imaging. Chemistry of Materials (2010) 22:6361-9
* Omerovic J, Clague MJ and Prior IA. Phosphatome profiling reveals PTPN2, PTPRJ and PTEN as potent negative regulators of PKB/Akt activation in Ras mutated cancer cells. Biochem. J. (2010) 246: 65-72
* Kim W, Khan NA, McMurray DN, Prior IA, Wang N, Chapkin RS. Regulatory activity of polyunsaturated fatty acids in T-cell signaling. Prog. Lipid Res. (2010) 49: 250-61
* Taylor AM, Wlodarski BW, Prior IA, Jarvis JC, Ranganath LR and Gallagher JA. Ultrastructural examination of tissue in a patient with alkaptonuric arthropathy reveals a distinct pattern of binding of ochronotic pigment. Rheumatology (2010) 49: 1412-14.

2009
* Omerovic J and Prior IA. Compartmentalised signalling: Ras proteins and signalling nanoclusters. FEBS J. (2009) 276: 1817-1826
* Henis YI, Hancock JF and Prior IA. Ras acylation, compartmentalization and signaling nanoclusters (Review). Molecular Membrane Biology (2009) 26: 80-92
* Lur G, Haynes LP, Prior IA, Gerasimenko OV, Feske S, Petersen OH, Burgoyne RD and Tepiken AV. Ribosome-free terminals of rough ER allow formation of STIM1 puncta and segregation of STIM1 from IP3 receptors. Curr. Biol. (2009) 19: 1648-53.
* Tong WC, Sweeney M, Jones CJP, Zhang H, O'Neill SC, Prior IA and Taggart MJ. Three-dimensional electron microscopic reconstruction of sarcoplasmic reticular arrangement in vascular smooth muscle with respect to mitochondria and the nucleus – further evidence of nanospaces and contacts. J. Cellular Mol. Med. (2009) i13: 995-8.
* Sée V, Free P, Cesbron Y, Nativo P, Shaheen, U, Rigden, D, Spiller D, Fernig DG, White MRH, Prior IA, Brust M, Lounis B and Lévy R. Cathepsin-L digestion of nanobioconjugates upon endocytosis. ACS Nano. (2009) 3: 2461-8.
* Ung D, Tung LD, Robinson I, Lu T, Caruntu G, Delaportas D, Alexandrou A, Prior IA and Thanh NTK. Variant shape growth of nanoparticles of metallic Fe-Pt, Fe-Pd and Fe-Pt-Pd alloys. Crystal Eng. Comm. (2009) 11: 1309-16
* Wilson R, Mehrabi M, Prior IA, Beckett A and Hutchinson A. A reliable method for attaching biological molecules to layer-by-layer self assemblies. Chem. Comm. (2009) 18: 2487-2489

2008
* Laude AJ and Prior IA. Ras isoform palmitoylation and localisation is modulated by the hypervariable linker domain. J. Cell Science (2008) 121: 421-7
* Omerovic J, Hammond DE, Clague MJ and Prior IA. Ras isoform abundance and signalling in human cancer cell lines. Oncogene (2008) 27: 2754-62
* Palmer ZJ, Rickman, C, Johnson JR, Lian L-Y, Mello LV, Booth D, Barclay JW, Graham ME, Burgoyne RD, Duncan RR, Prior IA, Morgan A. S-nitrosylation of syntaxin 1 at Cys145 is a regulatory switch controlling Munc18-1 binding. Biochem. J. (2008) 413: 479-91
* Nativo P, Prior IA and Brust M. Uptake and intracellular fate of surface-modified gold nanoparticles. ACS Nano (2008) 2: 139-1644
* Chapkin RS, Wang N, Fan Y-Y, Lupton JR and Prior IA. Docosohexaenoic acid alters the size and distribution of cell surface microdomains. Biochim. Biophys. Acta (2008) 1778: 466-71

2007
* Wilson R, Spiller DG, Prior IA, Veltkamp KJ and Hutchinson A. A simple method for preparing spectrally encoded magnetic beads for multiplexed detection. ACS Nano (2007) 1: 487-93
* Wilson R, Spiller DG, Prior IA, Bhatt R and Hutchinson A. Magnetic microspheres encoded with photoluminescent quantum dots for multiplexed detection. J. Materials Chemistry (2007) 17: 4400-4406
* Harila K, Salminen A, Prior I, Hinkula J and Suomalainen M. The Vpu-regulated endocytosis of HIV-1 Gag is clathrin-independent. Virology (2007). 369: 299-308
* Omerovic J, Laude AJ and Prior IA. Ras proteins: paradigms for compartmentalized and isoform-specific signaling. Cellular and Molecular Life Sciences. (2007) 64: 2575-89
* Sherwood MW, Prior IA, Voronina SG, Barrow SL, Woodsmith JD, Gerasimenko OV, Petersen OH and Tepikin AV. Activation of trypsinogen in large endocytic vacuoles of pancreatic acinar cells. Proc Natl Acad Sci U S A. (2007) 104:5674-9.

Selected earlier publications
* Hancock JF and Prior IA. Electron microscopic imaging of Ras signaling domains. Methods (2005) 37:165-72
* Rotblat B, Prior IA, Muncke C, Parton RG, Kloog Y, Henis YI and Hancock JF. Three separable domains regulate GTP-dependent association of H-ras with the plasma membrane. Mol. Cell Biol. (2004) 24:6799-810.
* Laude AJ and Prior IA. Plasma membrane microdomains: organization, function and trafficking (Review). Molecular Membrane Biology (2004) 21:193-205.
* Prior IA, Muncke C, Parton RG and Hancock JF. Direct visualization of Ras proteins in spatially distinct cell surface microdomains. J. Cell Biol. (2003) 160: 165-70.
* Prior IA and Hancock JF. Compartmentalization of Ras proteins. J. Cell Science. (2001) 114:1603-8.
* Prior IA, Harding A, Yan J, Sluimer J, Parton RG and Hancock JF. GTP-dependent segregation of H-ras from raft domains is required for efficient Raf activation. Nature Cell Biol. (2001) 3:386-75.
* Prior IA and Clague MJ. Detection of thiol modification following generation of reactive nitrogen species: analysis of synaptic vesicle proteins. Biochim. Biophys. Acta. (2000) 1475:281-286.
* Apolloni A, Prior IA, Lindsay M, Parton RG and Hancock JF. H-ras but not K-ras traffics to the plasma membrane through the exocytic pathway. Mol. Cell Biol. (2000) 20:2475-87.
* Prior IA and Clague MJ. Glutamate uptake occurs at an early stage of synaptic vesicle recycling. Curr. Biol. (1997) 7:353-6.


 

 

 


 
 

 

Favourite lab papers
Booth et al, EMBO J. (2011): great collaboration requiring skilled work by Dan to characterise mitotic spindle bridge components.

Omerovic et al, Oncogene (2008): unexpected insights into endogenous Ras isoform function and oncogenic signalling.

Laude et al, J. Cell Sci. (2008): new motifs characterised that are critical for normal Ras trafficking

Prior et al, J Cell Biol. (2003): novel method to analyse cell signalling microdomains provided important insights into Ras biology

Prior and Clague: BBA (1997): novel method to detect protein S-nitrosylation in complex protein mixtures. See also Palmer et al, Biochem J. (2008) where S-nitrosomimetic mutants have been developed.