From biorheology to
biofluid mechanics: Elucidating the behavior of Biofluids in complex flows
Yannis Dimakopoulos
University of Patras, Greece
Abstract
In recent decades, the biomedical community has
been reluctant to adopt advanced rheological constitutive models that describe
the complex behavior of biological fluids such as blood and blood plasma. Moreover,
the limited amount of relevant work in the literature pertains, mainly, to
benchmark case studies and prototype flows while the utilization of those
models for the prediction of complex flow dynamics or fluid-structure interactions,
e.g., analysis of hemodynamics in micro-vessels,
has been overlooked.
Widely embracing those models within the
scientific community has been, primarily, constrained by the complexity of the
proposed constitutive laws and the lack of a systematic framework for
evaluating the model parameters and validating the predicted results.
Therefore, the current talk focuses on a wide range of contributions from the
Fluids Lab (http://fluidslab.chemeng.upatras.gr/) to the rheological modeling of
various biological systems and the simulation of their flows towards
alleviating the aforementioned issues.
We explore three major topics:
(i) the investigation
of the blood plasma viscoelasticity[1],
(ii) the response of the endothelial glycocalyx
(EG) to variations of the hemodynamic environment via DNS and analytical models[2],
and
(iii) the constitutive modeling of blood as a Thixo-Elasto-Viscoplastic (TEVP) material[3]-[5].
References
[1] Varchanis,
S., Dimakopoulos, Y., Wagner, C., & Tsamopoulos, J. (2018). How viscoelastic is human
blood plasma? Soft Matter, 14(21), 4238–4251. doi:10.1039/c8sm00061a
[2] Mitsoulas,
V., Varchanis, S., Dimakopoulos,
Y., & Tsamopoulos, J. (2021). Dynamics and
Apparent Permeability of the Glycocalyx Layer: Start-Up and Pulsating Shear
experiments in-silico. Submitted for publication in PRF.
[3] Varchanis,
S., Makrigiorgos, G., Moschopoulos,
P., Dimakopoulos, Y., & Tsamopoulos,
J. (2019). Modeling the rheology of thixotropic elasto-visco-plastic materials. Journal of Rheology, 63(4),
609–639. doi:10.1122/1.5049136
[4] Giannokostas,
K., Moschopoulos, P., Varchanis,
S., Dimakopoulos, Y., & Tsamopoulos,
J. (2020). Advanced Constitutive Modeling of the Thixotropic Elasto-Visco-Plastic Behavior of
Blood: Description of the Model and Rheological Predictions. Materials, 13(18),
4184. doi:10.3390/ma13184184
[5] Giannokostas,
K., Photeinos, D., Dimakopoulos,
Y., & Tsamopoulos, J. (2021). Quantifying
the non-Newtonian effects of pulsatile hemodynamics in tubes. Journal of
Non-Newtonian Fluid Mechanics 298, 104673.
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