The increasing threat of pathogen resistance to antibiotics requires the development of novel antimicrobial strategies. I will present two genetic strategies that aim to sensitize bacteria to antibiotics and selectively kill antibiotic-resistant bacteria. The first strategy is based on dominant sensitive genes that reverse antibiotic resistance of bacteria. The second uses temperate phages to deliver a functional CRISPR-Cas system into the genome of antibiotic-resistant bacteria. The delivered CRISPR-Cas system destroys both antibiotic resistance-conferring plasmids and genetically-modified lytic phages. This linkage between antibiotic-sensitization and protection from lytic phages is a key feature of the strategy. It allows programming of lytic phages to kill only antibiotic-resistant bacteria while protecting antibiotic-sensitized bacteria. Phages designed according to this strategy may be used on hospital surfaces and hand-sanitizers to facilitate replacement of antibiotic-resistant pathogens with sensitive ones.