School of Medicine - Year 1 MBChB Curriculum

Lecture 14: "How the gut protects itself"

1. the defensive role of the mucosal barrier and the consequences for the gut when protection fails
2. how the gastrointestinal epithelium responds when insult leads to injury
3. how the gut detects and removes infectious agents
4. the mechanisms to sense and remove any damaged/mutated cells
5. the mechanisms and regulation of vomiting

Useful links

• The gastrointestinal barrier
   
  
• Dignass AU (2001). Mechanisms and modulation of intestinal epithelial repair. Inflamm. Bowel Dis., 7(1): 68-77
   
  
• Wallace JL, Granger DN (1996). The cellular and molecular basis of gastric mucosal defense. FASEB J. 1996, 10(7):731-40
   
  
• Wallace JL (2008). Prostaglandins, NSAIDs, and Gastric Mucosal Protection: Why Doesn't the Stomach Digest Itself? Physiol. Rev. 2008, 88(4):1547-65
   
  
• The immune system
   
  
• apoptosis
   
  
• Physiology of vomiting