Our research focuses on the cellular response to environmental oxygen level variations and their impact on cell fate. As the environment in solid tumours is hypoxic (low oxygen), or subject to episodes of hypoxia and re-oxygenation, our research has direct significance to cancer. We work across scales from single molecule to small organism, using advanced imaging technologies to elucidate the role of hypoxia on cancer cell phenotype. Building on collaborations with leading national clinical institutions (the Alder Hey Children Hospital and the Clatterbridge Cancer Centre), We have concentrated our research on the effects of hypoxia in paediatric (neuroblastoma, medulloblastoma) and brain tumours (glioblastoma).