2010

Clague M.J. and Urbé S. (2010) Ubiquitin: Same molecule, different degradation pathways. Invited Minireview for Cell, in press.

Polson H.E.J., de Lartigue J., Rigden D.J., Marco Reedijk, Urbé S., Clague M.J., and Tooze S.A. (2010) Mammalian Atg18 (WIPI2) localizes to omegasome-anchored phagophores and positively regulates LC3 lipidation. Autophagy 6, 506-522.

Sacco J., Coulson J.M., Clague M.J. and Urbé S. (2010) Emerging roles of deubiquitinases in cancer associated pathways. IUBMB Life 62, 140-157.

2009

Popoff V., Mardones G.A., Bai S.K., Chambon V., Tenza B., Burgos P.V., Shi A., Benaroch P., Urbé S. Lamaze C., Grant B., Raposo G. and Johannes L. (2009) Analysis of articulation between clathrin and retromer in retrograde sorting on early endosomes. Traffic 10, 1868-1880.

Buus R., Faronato M. Hammond D.E., Urbé S. and Clague M.J. (2009) Regulation of the HGF-mediated cell scattering response by deubiquitinating enzymes. Current Biology 19, 1463-1466.

Komander D., Clague M.J. and Urbé S. (2009) Breaking the chains: structure and function of the deubiquitinases. Nature Reviews Molecular Cell Biology 10, 550-563.

Liu H., Buus R., Clague M.J. and Urbé S. (2009) Regulation of ErbB2 status by the proteasomal DUB POH1. PLOS One 4(5), e5544.

de Lartigue J., Polson H., Feldmann M., Shokat K., Tooze S.A., Urbé S. and Clague M.J. (2009) PIKfyve regulation of endosome-linked pathways. Traffic 10, 883-893.

Rigden D.J., Liu H., Hayes S.D., Urbé S. and Clague M.J. (2009) Bioinformatic discovery of novel human MIT domains. FEBS Lettrs. 583, 872-878.

Clague M.J., Urbé S. and de Lartigue J. (2009) Phosphoinositides and the endocytic pathway. Experimental Cell Research 9, 1627-1631.

2008

Clague M.J. and Urbé S. (2008) Quick Guide: Multivesicular bodies. Current Biology 18, R402-R404.

Clague M.J., Coulson J.M. and Urbé S. (2008) Deciphering Histone H2A deubiquitination. Genome Biology 9, 202.

2007

Row P.E., Liu H., Hayes S. Welchman R., Charalabous P., Hofmann K., Clague M.J., Sanderson C.M. and Urbé S. (2007) The MIT domain of UBPY constitutes a CHMP binding and endosomal localisation signal required for efficient EGF receptor degradation. J. Biol. Chem. 282, 30929-37

Williams R.L. and Urbé S. (2007) The emerging shape of the ESCRT machinery. Nature Reviews Mol Cell Biol. 8, 355-368.[abstract]

2006

Clague M.J and Urbé S. (2006) Endocytosis: the DUB version. Trends in Cell Biology 16, 551-559 [abstract]

Lorenzo O., Urbé,S. and Clague,M.J. (2006) Systematic analysis of myotubularins: heteromeric interactions, subcellular localisation and endosome related functions. J. Cell Sci. 119, 2953-2959 [abstract].

Row P.E., Prior,I.A., McCullough J., Clague M.J., Urbé S. (2006) The ubiquitin isopeptidase UBPY regulates endosomal ubiquitin dynamics and is essential for receptor down-regulation. J. Biol. Chem. 281, 12618-12624 [abstract].

McCullough J., Row P.E., Lorenzo, O. Doherty M., Beynon R., Clague M.J., Urbé S. (2006) Activation of the endosome associated deubiquitinating enzyme AMSH by STAM, a component of the multivesicular body pathway.Current Biology 16, 160-165 [abstract].

2005

Row P.E., Clague M.J. and Urbé S. (2005) Growth factors induce differential phosphorylation profiles of the Hrs-STAM complex: a common node in signalling networks with signal-specific properties.Biochem. J. 389, 629-636 [article].

Abella J.V., Peschard P., Naujokas M.A., Lin T., Saucier C., Urbé S. and Park M. (2005) Met/HGF receptor ubiquitination suppresses transformation and is required for Hrs phosphorylation. Mol. Cell Biol. 25, 9632-9645. [abstract]

Regan-Klapisz E., Sorkina I., Voortman J., de Keizer P., Roovers R.C., Verheesen P., Urbé S., Fallon L., Fon E.A., Verkleij A., Benmerah A. and van Bergen en Henegouwen P.M.P. (2005) Ubiquilin recruits Eps15 into ubiquitin-rich cytoplasmic aggregates via an ubiquitin-like (UBL)-UIM interaction. J. Cell Sci. 118; 4437-50. [abstract]

Lorenzo O., Urbé S. and Clague M.J. (2005) Analysis of phosphoinositide binding domain function in myotubularin related protein 3, MTMR3. J. Cell Sci. 118, 2005-2012 [abstract].

Urbé S. (2005) Ubiquitin, endocytosis and protein sorting. Essays in Biochemistry, Portland Press, 41, 81-98. [abstract]

2004

Carter S., Urbé S. and Clague M.J. (2004) The Met receptor degradation pathway: requirement for K48-linked polyubiquitin independent of proteasome activity. J. Biol. Chem. 51, 52835-52839 [abstract].

McCullough J., Clague M.J. and Urbé S. (2004) AMSH: an endosome associated ubiquitin isopeptidase. J. Cell Biol. 166, 487-492 [abstract].

2003

Clague M.J. and Urbé S. (2003) Hrs function: viruses provide the clue. Trends in Cell Biology 13, 603-606 [abstract].

Urbé S., Sachse M., Row P.E., Preisinger C., Barr F.A., Strous G., Klumperman J. and Clague,M.J. (2003) The UIM domain of Hrs couples receptor sorting to vesicle formation. J. Cell Sci. 116, 4169-4179 [abstract].

Hammond,D.E. Carter,S., McCullough,J. Urbé,S, Vande Woude,G. and Clague M.J. (2003) Endosomal dynamics determine Met signalling. Mol. Biol. Cell 14, 1346-1354 [abstract].

2002

Sachse M., Urbé S., Oorschot V., Strous G. and Klumperman J. (2002) Bi-layer clathrin coats on endosomal vacuoles are involved in protein sorting towards lysosomes. Mol. Biol. Cell, 13, 1313-1328. [abstract]

2001

Walker D.M., Urbé S., Dove S.K., Tenza D., Raposo G. and Clague M.J. (2001) Characterization of MTMR3: an inositol lipid 3-phosphatase with novel substrate specificity. Current Biology 11, 1600-1605. [abstract]

Clague,M.J. and Urbé,S. (2001) The interface of receptor trafficking and signaling, J. Cell Sci.,114, 3075-3081. [abstract]

Hammond,D.E., Urbé,S., Vande Woude,G.F. and Clague,M.J. (2001) Down-regulation of Met, the receptor for hepatocyte growth factor. Oncogene, 20, 2761-2770.[abstract]

Mills,I.G., Urbé,S. and Clague,M.J. (2001) Relationships between EEA1 binding partners and their role in endosome fusion. J. Cell Sci., 114, 1959-1965 [full article PDF]

Wendler F., Page L., Urbé S. and Tooze S.A. (2001) Homotypic fusion of immature secretory granules during maturation requires syntaxin 6. Mol. Biol. Cell. 12, 1699-1709. [abstract]

2000

Urbé S., Mill ,I.G., Stenmark H., Kitamura N. and Clague M.J. (2000) Endosomal localisation and receptor dynamics determine tyrosine phosphorylation of Hrs. Molecular and Cellular Biology, 20, 7685-7692.[abstract] [full article PDF]

Earlier publications

Urbé S. Page L. and Tooze S.A. (1998) Homotypic fusion of immature secretory granule during maturation in a cell-free assay. J. Cell Biol. 143, 1831-1844.

Urbé S., Tooze S.A. and Barr F.A. (1997) Formation of secretory vesicles in the biosynthetic pathway. BBA Molecular Cell Research, 1358, 6-22.

Urbé S, Dittié A. and Tooze S.A. (1997), pH-dependent processing of Secretogranin II by the endopeptidase PC2 in immature secretory granules. Biochem. J. 321, 65-74.

Ullrich O., Reinsch S., Urbé S., Zerial M. and Parton R.G. (1996) Rab11 regulates recycling through the pericentriolar recycling endosome. J. Cell Biol. 135, 913-924.

Clague M.J., Urbé S., Aniento F. and Gruenberg J.(1994) Vacuolar-ATPase activity is required for endosomal carrier vesicle formation. J. Biol. Chem. 269, 21-24.

Urbé S., Huber L.A., Zerial M., Tooze S.A. and Parton R.G. (1993) Rab11p, a small GTPase associated with both constitutive and regulated secretory pathways in PC12 cells. FEBS Lett., 334, 175-182.