Richard Barrett-Jolley

Research Interests

1. How the head rules the heart

Mathematically modelling central cardiovascular control, with various techniques including Heart Rate Variability Analysis (HRV), Bayesian statistics and Deep Learning In vitro studies of the properties and modulation of ion channel currents in the PVN , especially those of neurones involved with the cardiovascular response to psychological stress, temperature circadian rhythm and osmolarity. For a very general explanation, see below. This is important for both human and veterinary medicine.

2. The Matrix Revolution

Investigation of the peculiar pharmacology of chondrocytes and their ion channels. We find that the ion channels of chondrocytes have two linked functions in the control of cellular volume:

• They act as "osmolyte" channels as proposed by others
• They set the membrane potential, which is vital to the control of volume

We think pharmacological control of chondrocyte volume could be important for modifying the progression of OA.

Teaching

Vet Students (Introductory/Neuropharmacology/Veterinary Neuroscience): Most materials are locked under Canvas for registered students only.

Techniques

• • Single-channel and whole-cell patch-clamp electrophysiology
• • Heart Rate variability and frequency analysis
• • Bioinformatic analysis of transcriptomic data
• • Mathematical modelling of cell function
• • Deep Learning
• • Bayesian Modelling

PhD Opportunities

PhD positions are always available for self-funding students. Please see FindAPhD. Projects focus on Ion Channel function in connection with cardiovascular control and musculo-skeletal system. Please contact me if you're interested! Modelling and DeepLearning. Contact: Official University Home Page

Funding

BBSRC, IMB, MRC

RBJ is a Chair/Full Professor at Liverpool University.