UKBiotech

 “Excellence in Biomaterials & Tissue Engineering Research”

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UKBiotec was established in 2007 and is based in Liverpool.  It was founded by two principal scientists from the UK Centre for Tissue Engineering, a world class centre of Tissue Engineering, Biomaterials and Biocompatibility research, initially funded by the UK Research Councils, based at the University of Liverpool.

UKBiotec’s commercial direction is driven by the demand for services in the assessment of biocompatibility and efficacy in tissue regeneration.  The broad objective is to commercialise and bring to clinic novel therapeutic paradigms in the field regenerative medicine.

 

Members of the Board

Hunt John.JPG

John Hunt, PhD DSc

Scientific Director and Company Secretary

John Hunt is a Reader in Tissue Engineering with academic interests in techniques to assess the cellular and molecular mechanisms of biocompatibility and tissue engineering.  He is on the management committee of the Liverpool Institute for Nanoscale Science, Engineering and Technology.  He is associate editor for Biomaterials, subject editor for Biomaterials in Current Opinion in Solid State and Materials Science, member of the editorial boards for European Cells and Materials and International Journal of Adipose Tissue

Rhodes Nick.JPG

Nick Rhodes, PhD

Managing Director and CFO

Nick Rhodes a Reader in Tissue Engineering with academic interests in biocompatibility, biomaterials, stem cells and tissue engineering.  He is on the management committee of the Liverpool Centre for Glycobiology.  He is an officer of the executive committee of the Tissue Engineering and Regenerative Medicine International Society (TERMIS) and member of the editorial board of the International Journal of Adipose Tissue.

List of Selected Recent Publications

·        Rhodes NP. Inflammatory signals in the development of tissue-engineered soft tissue. Biomaterials 2007;28:5131-6. doi:10.1016/j.biomaterials.2007.08.004

·        Hunt JA. The criticality of quantitative analysis and reproducibility for the development of interactive regenerative treatments. Biomaterials 2007;28:5128-30. doi:10.1016/j.biomaterials.2007.07.016

·        Chen R, Hunt JA. Biomimetic materials processing for tissue-engineering processes. Journal of Materials Chemistry 2007;17:3974-9. doi:10.1039/b706765h

·        Rhodes NP, di Bartolo C, Hunt JA. Analysis of the cellular infiltration of benzyl-esterified hyaluronan sponges implanted in rats. Biomacromolecules 2007;8:2733-8. doi:10.1021/bm070368p

·        Rhodes NP, di Bartolo C, Bellini D, Hunt JA. Induction of adipose tissue regeneration by chemically-modified hyaluronic acid. International Journal of Nano and Biomaterials in press.

·        Rhodes NP, Wilson DJ, Williams RL. The effect of gas plasma modification on platelet and contact phase activation processes. Biomaterials 2007;28:4561-70. doi:10.1016/j.biomaterials.2007.07.008

·        Tang ZG, Rhodes NP, Hunt JA. Control of the domain microstructures of PLGA and PCL binary systems: Importance of morphology in controlled drug release. Chemical Engineering Research & Design 2007;85:1044-50. doi:10.1205/cherd06217

·        Mirsadraee S, Wilcox HE, Watterson KG, Kearney JN, Hunt JA, Fisher J, Ingham E. Biocompatibility of acellular human pericardium. Journal of Surgical Research 2007;143:407-14. doi:10.1016/j.jss.2007.01.026 

·        Hemmrich K, Van de Sijpe K, Rhodes NP, Hunt JA, di Bartolo C, Pallua N, Blondeel P, von Heimburg D. Autologous in vivo adipose tissue engineering in hyaluronan-based gels – a pilot study. Journal of Surgical Research in press. doi:10.1016/j.jss.2007.03.017

·        Oates M, Chen R, Duncan M, Hunt JA. The Angiogenic potential of three-dimensional open porous synthetic matrix materials. Biomaterials 2007;28:3679-86. doi:10.1016/j.biomaterials.2007.04.042

·        Andrews KD, Hunt JA, Black RA. Effects of sterilisation method on surface topography and in-vitro cell behaviour of electrostatically spun scaffolds. Biomaterials 2007;28:1014-26. doi:10.1016/j.biomaterials.2006.10.014 

·        Brama M, Rhodes N, Hunt J, Ricci A, Teghil R, Migliaccio S, Della Rocca C, Leccisotti S, Lioi A, Scandurra M, De Maria G, Ferro D, Pu F, Panzini G, Politi L, Scandurra R. Effect of titanium carbide coating on the osseointegration response in vitro and in vivo. Biomaterials 2007;28:595-608. doi:10.1016/j.biomaterials.2006.08.018 

·        Baldwin L, Hunt JA. Host inflammatory response to NiCr, CoCr, and Ti in a soft tissue implantation model. Journal of Biomedical Materials Research 2006;79:574-81. doi:10.1002/jbm.a.30856

·        Curran JM, Chen R, Hunt JA. The guidance of human mesenchymal stem cell differentiation in vitro by controlled modifications to the cell substrate. Biomaterials 2006;27:4783-93. doi:10.1016/j.biomaterials.2006.05.001 

·        Richardson SM, Walker RV, Parker S, Rhodes NP, Hunt JA, Freemont AJ, Hoyland JA. Intervertebral disc cell-mediated mesenchymal stem cell differentiation. Stem Cells 2006;24:707-16. doi:10.1634/stemcells.2005-0205

·        Chen R, Curran SJ, Curran JM, Hunt JA. The use of poly(L-lactide) and RGD modified microspheres as cell carriers in a flow intermittency bioreactor for tissue engineering cartilage. Biomaterials 2006;27:4453-60. doi:10.1016/j.biomaterials.2006.04.011 

·        Tang ZG, Hunt JA. The effect of PLGA doping of polycaprolactone films on the control of osteoblast adhesion and proliferation in vitro. Biomaterials 2006;27:4409-18. doi:10.1016/j.biomaterials.2006.04.009 

·        Richardson SM, Curran JM, Chen R, Vaughan-Thomas A, Hunt JA, Freemont AJ, Hoyland JA. The differentiation of bone marrow mesenchymal stem cells into chondrocyte-like cells on poly-L-lactic acid (PLLA) scaffolds. Biomaterials 2006;27:4069-78. doi:10.1016/j.biomaterials.2006.03.017 

·        Fujiyoshi K, Hunt JA. The effect of particulate material on the regulation of chemokine receptor expression in leukocytes. Biomaterials 2006;27:3888-96. doi:10.1016/j.biomaterials.2006.02.047

·        Rhodes NP, Bellón JM, Buján MJ, Soldani G, Hunt JA. Inflammatory response to a novel series of siloxane-crosslinked polyurethane elastomers having controlled biodegradation. Journal of Materials Science: Materials in Medicine 2005;16:1207-11. doi:10.1007/s10856-005-4730-7

·        Marques AP, Reis RL, Hunt JA. The effect of starch-based biomaterials on leukocyte adhesion and activation in vitro. Journal of Materials Science: Materials in Medicine 2005;16:1029-43. doi:10.1007/s10856-005-4757-9

·        Curran SJ, Chen R, Curran JM, Hunt JA. Expansion of human chondrocytes in an intermittent stirred flow bioreactor, using modified biodegradable microspheres. Tissue Engineering 2005;11:1312-22. doi:10.1089/ten.2005.11.1312

·        Tang ZG, Callaghan JT, Hunt JA. The physical properties and response of osteoblasts to solution cast films of PLGA doped polycaprolactone. Biomaterials 2005;26:6618-24. doi:10.1016/j.biomaterials.2005.04.013 

·        Marques AP, Reis RL, Hunt JA. An in vivo study of the host response to starch-based polymers and composites subcutaneously implanted in rats. Macromolecular Bioscience 2005;5:775-85. doi:10.1002/mabi.200500010

·        Curran JM, Chen R, Hunt JA. Controlling the phenotype and function of mesenchymal stem cells in vitro by adhesion to silane-modified clean glass surfaces. Biomaterials 2005;26:7057-67. doi:10.1016/j.biomaterials.2005.05.008

·        Hunt JA, Callaghan JT, Sutcliffe CJ, Morgan RH, Halford B, Black RA. The design and production of Co-Cr alloy implants with controlled surface topography by CAD-CAM method and their effects on osseointegration. Biomaterials 2005;26:5890-7. doi:10.1016/j.biomaterials.2005.03.004 

·        Al-Badairy H, Tatlock G, Fawcett S, Beahan P, Hunt J. FEG-SEM investigation of α-alumina scales formed on FeCrAlY alloys oxidised at 12000oC. Journal of Physics. IV France. 2005;124:17-24. Reprint PDF

·        Baldwin L, Flanagan BF, Hunt JA. Flow cytometric measurement of phagocytosis reveals a role for C3b in metal particle uptake by phagocytes. Journal of Biomedical Materials Research 2005;73:80-5. doi:10.1002/jbm.a.30252

·        Curran JM, Gallagher JA, Hunt JA. The inflammatory potential of biphasic calcium phosphate granules in osteoblast/macrophage co-culture. Biomaterials 2005;26:5313-20. doi:10.1016/j.biomaterials.2005.01.065 

·        Feugier P, Black RA, Hunt JA, How TV.  Attachment, morphology and adherence of human endothelial cells to vascular prosthesis materials under the action of shear stress. Biomaterials 2005;26:1457-66. doi:10.1016/j.biomaterials.2004.04.050

·        Rhodes NP. Biocompatibiltiy testing of tissue engineered products. Vox Sanguinis 2004;87 Suppl 2:161-3. doi:10.1111/j.1741-6892.2004.00477.x

·        Williams RL, Wilson DJ, Rhodes NP. Stability of plasma-treated silicone rubber and its influence on the interfacial aspects of blood compatibility. Biomaterials 2004;25:4659-73. doi:10.1016/j.biomaterials.2003.12.010

·        Rhodes NP, Srivastava JK, Smith RF, Longinotti C. Heterogeneity in proliferative potential of ovine mesenchymal stem cell colonies. Journal of Materials Science: Materials in Medicine 2004;15:397-402. doi:10.1023/B:JMSM.0000021109.21807.f0

·        Rhodes NP, Srivastava JK, Smith RF, Longinotti C. Metabolic and histological analysis of mesenchymal stem cells grown in 3-D hyaluronan-based scaffolds. Journal of Materials Science: Materials in Medicine 2004;15:391-95. doi:10.1023/B:JMSM.0000021108.74004.7e

·        Smith P, Rhodes NP, Ke Y, Foster CS. Relationship between upregulated oestrogen receptors and expression of growth factors in cultured, human, prostatic stromal cells exposed to estradiol or dihydrotestosterone. Prostate Cancer and Prostatic Diseases 2004;7:57-62. doi:10.1038/sj.pcan.4500692

·        Marques AP, Reis RL, Hunt JA. Cytokine secretion from mononuclear cells cultured in vitro with starch-based polymers and poly-L-lactide. Journal of Biomedical Materials Research 2004;71:419-29. doi:10.1002/jbm.a.30155

·        Jackson PV, Hunt JA, Doherty PJ, Cannon A, Gilson P. Hydrophilicity of 3-D biomaterials: The Washburn equation. Journal of Materials Science: Materials in Medicine 2004;15:507-11. doi:10.1023/B:JMSM.0000021129.60818.ca

·        Tang ZG, Black RA, Curran JM, Hunt JA, Rhodes NP, Williams DF. Surface properties and biocompatibility of solvent-cast poly[ε-caprolactone] films. Biomaterials 2004;25:4741-8. doi:10.1016/j.biomaterials.2003.12.003

·        Wilson DJ, Rhodes NP, Williams RL. Surface modification of a segmented polyetherurethane using a low-powered gas plasma and its influence on the activation of the coagulation system. Biomaterials 2003;24:5069-81. doi:10.1016/S0142-9612(03)00423-X

·        Vallabhaneni SR, Gilling-Smith GL, Brennan JA, Heyes RR, Hunt JA, How TV, Harris PL. Can intrasac pressure monitoring reliably predict failure of endovascular aneurysm repair? Journal of Endovascular Therapy 2003 10:524-30. doi:10.1583/1545-1550(2003)010<0524:CIPMRP>2.0.CO;2

·        Rice JM, Hunt JA, Gallagher JA, Hanarp P, Sutherland DS, Gold J. Quantitative assessment of the response of primary derived human osteoblasts and macrophages to a range of nanotopography surfaces in a single culture model in vitro. Biomaterials 2003;24:4799-818. doi:10.1016/S0142-9612(03)00381-8 

·        Alves CM, Reis RL, Hunt JA. Preliminary study on human protein adsorption and leukocyte adhesion to starch-based biomaterials. Journal of Materials Science: Materials in Medicine 2003;14:157-65. doi:10.1023/A:1022023930825

·        Marques AP, Reis RL, Hunt JA. Evaluation of the potential of starch-based biodegradable polymers in the activation of human inflammatory cells. Journal of Materials Science: Materials in Medicine 2003;14:167-73. doi:10.1023/A:1022028114896

·        Rice JM, Hunt JA, Gallagher JA. Quantitative evaluation of the biocompatible and osteogenic properties of a range of biphasic calcium phosphate (BCP) granules using primary cultures of human osteoblasts and monocytes. Calcified Tissue International 2003;72:726-36. doi:10.1007/s00223-002-2045-y

·        Michanetzis GPA, Missirlis YF, Rhodes NP, Williams DF, Eloy R, Lemm W. Influence of test protocol in determining the blood response to model polymers. Journal of Materials Science: Materials in Medicine 2002;13:757-65. doi:10.1023/A:1016166807299

·        Smith P, Rhodes NP, Ke Y, Foster CS. Upregulation of estrogen and androgen receptors modulate expression of FGF-2 and FGF-7 in human, cultured, prostatic stromal cells exposed to high concentrations of estradiol. Prostate Cancer and Prostatic Diseases 2002;5:105-10. doi:10.1038/sj.pcan.4500571

·        Hunt JA, Shoichet MS. Biomaterials: drug delivery systems. Current Opinion in Solid State & Materials Science 2002;6:281. doi:10.1016/S1359-0286(02)00115-8 

·        Swindle EJ, Hunt JA, Coleman JW. A comparison of reactive oxygen species generation by rat peritoneal macrophages and mast cells using the highly sensitive real-time chemiluminescent probe Pholasin: inhibition of antigen-induced mast cell degranulation by macrophage-derived hydrogen peroxide. Journal of Immunology  2002;169:5866-73. Reprint PDF

·        Pu FR, Williams RL, Markkula T, Hunt JA. Expression of leukocyte-endothelial cell adhesion molecules on monocyte adhesion to human endothelial cells on plasma treated PET and PTFE in vitro. Biomaterials 2002;23:4705-18. doi:10.1016/S0142-9612(02)00219-3

·        Baldwin L, Flanagan BF, McLaughlin PJ, Parkinson RW, Hunt JA, Williams DF. A study of interface membranes from revision accord knee arthroplasty: the role of T lymphocytes. Biomaterials 2002;23:3007-14. doi:10.1016/S0142-9612(02)00059-5  

·        Pu FR, Williams RL, Markkula T, Hunt JA. Effects of plasma treated PET and PTFE on expression of adhesion molecules by human endothelial cells in vitro. Biomaterials Vol 2002;23:2411-28. doi:10.1016/S0142-9612(01)00377-5 

·        Marques AP, Reis RL, Hunt JA. The biocompatibility of novel starch based polymers and composites: in vitro studies. Biomaterials 2002;23:1471-8. doi:10.1016/S0142-9612(01)00272-1

·        Markkula TK, Hunt JA, Pu FR. Williams RL. Surface chemical derivatization of plasma-treated PET and PTFE. Surface and Interface Analysis 2002;34:583-7. doi:10.1002/sia.1365

·        Pu FR, Williams RL, Markkula TK, Hunt JA. Monocyte adhesion and adhesion molecule expression on human endothelial cells on plasma-treated PET and PTFE in vitro. Journal of Materials Science: Materials in Medicine 2001;12:971-7. doi:10.1023/A:1012861116388

·        Hunt JA, Shoichet M.  Biomaterials: surface interactions. Current Opinion in Solid State & Materials Science 2001;5:161-2. doi:10.1016/S1359-0286(01)00012-2 

·        Hemingway R, Williams RL, Hunt JA, Rudge SJ. The influence of bracket type on the force delivery of Ni-Ti archwires. European Journal of Orthodontics 2001;23:233-41. doi:10.1093/ejo/23.3.233

·        Smith P, Rhodes NP, Ke Y, Foster CS. Modulating effect of estrogen and testosterone on prostatic stromal cell phenotype differentiation induced by noradrenaline and doxazosin. Prostate 2000;44:111-7. doi:10.1002/1097-045(20000701)44:2<111::AID-PROS3>3.0.CO;2-3

·        Briggs MC, Grierson I, Hiscott P, Hunt JA. Active scatter factor (HGF/SF) in proliferative vitroretinal disease.  Investigative Ophthalmology & Visual Science 2000;41:3085-94. Reprint PDF

·        Davey PC, Zuzel M, Kamiguti AS, Hunt JA, Aziz KA. Activation-dependant proteolytic degradation of polymorphonuclear CD11b. British Journal of Haematology 2000;111:934-42. doi:10.1046/j.1365-2141.2000.02401.x