Bacteriophage-host relationships in the human respiratory tract


Kristen Gulino1, Adam Geber1, Alan Twaddle1, Naftali Kaminski2, Barbara Methe3, Alison Morris4, Elodie Ghedin1

1Center for Genomics & Systems Biology, Department of Biology, New York University, New York, NY, United States
2Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Yale School of Medicine, New Haven, CT, United States
3Department of Microbial and Environmental Genomics, J. Craig Venter Institute, Rockville, MD, United States
4Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States


Bacteriophages are the most abundant biological entities on Earth. They are known to be involved in the regulation of microbial ecology, diversity, and virulence. Their relationships with their bacterial hosts and their functional importance in the respiratory tract are however poorly understood in both health and disease. We characterized the viromes found in the bronchoalveolar lavages (BAL) of patients with lung disorders such as alpha-1 anti-trypsin deficiency and sarcoidosis. Our goal is to explore the taxonomy, diversity, and functionality of the identified phages to understand the role they play in structuring and influencing the lung microbiome. Additionally, bacterial 16S data will be integrated with this virome data to explore phage-host dynamics in the lung during disease. This work will increase our understanding of the ecological relationships between phages and their hosts in the human respiratory tract.






Reference:
Posters Day 2-T03-Pos-31
Session:
Posters Covering Ecology, Host population control, Co-Evolutionary dynamics and Subversion/Evasion of Host Defences
Presenters:
Kristen Gulino
Session:
Day 2 Posters Covering: Ecology, Host population control, Co-evolutionary dynamics and Subversion/Evasion of host defences
Presentation type:
Poster presentation
Room:
Poster Halls
Date:
Tuesday, 19 July 2016
Time:
12:05 - 15:00