Dr Faviel Gonzalez
Post-Doctoral Research Associate
Tel: +44 (0) 151 795 4555
Affiliations
- Member of the Post-genomic Bioinformatics Group, University of Liverpool.
Collaboration Groups
- European Network of the HLA diversity for histocompatibility, clinical transplantation, epidemiology and population genetics.
- A Europe-wide Strategy to enhance Transplantation of highly sensitized patients on basis of Acceptable HLA Mismatches.
Research Interests
Bioinformatics, Proteomics, Immunogenetics, Population Genetics.
Current project
My research is focussed on the development of an open-source software for the analysis of quantitative proteomics data. The software includes the integration of quantitative methods, definition of standards for data exchange and development of an user-friendly environment for the submission and (re)analysis of proteomics datasets.
Other projects
I have also participated in the development of bioinformatics web-based tools for the analysis of several immune genes such as HLA, KIR, MIC and different cytokine gene polymorphisms. Some of the developments include the construction of a website for the analysis of allele, haplotype and genotype frequencies in different human populations. As part of data standardisation, I am also interested on data exchange protocols. At present, I am on charge of the development and maintenance of the www.allelefrequencies.net website.
Publications
2013
- Walzer M, Qi D, Mayer G, Uszkoreit J, Eisenacher M, Sachsenberg T, Gonzalez-Galarza FF , Fan J, Bessant C, Deutsch EW, Reisinger F, Vizcaino JA, Medina-Aunon JA, Albar JP, Kohlbacher O and Jones AR The mzQuantML data standard for mass spectrometry-based quantitative studies in proteomics Molecular and cellular proteomics 2013 (In press)
- Gonzalez-Galarza FF , Qi D and Jones AR A tutorial for software development in quantitative proteomics using PSI standard formats Biochimica et Biophysica Acta 2013 (In press)
- Takeshita LYC, Gonzalez-Galarza FF , dos Santos EJM, Maia MHT, Rahman MM, Zain SMS, Middleton D and Jones AR A database for curating the associations between killer-cell immunoglobulin-like receptors and diseases in worldwide populations Databases 2013 (In press)
- Shangmugasundram A, Gonzalez-Galarza FF , Wastling J, Vasieva O, Jones AR Library of Apicomplexan Metabolic Pathways: A manually curated database for metabolic pathways of apicomplexan parasites Nucleic Acid Research 2013 41:D706-D713. [Full Text - Free Access]
- Hollenbach JA, Augusto DG, Alaez C, Bubnova L, Fae I, Fischer G, Gonzalez-Galarza FF Gorodezky C, Karabon L, Kusnierczyk P, Noble J, Rickards O, Roberts C, Schaffer M, Shi L, Tavoularis S, Trachtenberg E, Yao Y and Middleton D. 16th IHIW: Population Global Distribution of Killer Immunoglobulin-like Receptor (KIR) and Ligands International Journal of Immunogenetics 2013 40(1): 39-45. [Abstract]
- Gonzalez-Galarza FF , Mack SJ, Hollenbach J, Fernandez-Vina M, Setterholm M, Kempenich J, Marsh SGE, Jones AR, Middleton D and The HLA Rare Allele Consortium. 16th IHIW: Extending the number of resources and bioinformatics analysis for the investigation of HLA rare alleles International Journal of Immunogenetics 2013 40(1): 60-65. [Abstract]
2012
- Gonzalez-Galarza FF , Lawless C, Hubbard S, Fan J, Bessant C, Hermjakob H and Jones AR. A critical appraisal of techniques, software packages and standards for quantitative proteomic analysis OMICS 2012 16(9): 431-442. [Abstract]
- Qi D, Brownridge P, Xia D, Mackay K, Gonzalez-Galarza FF, Kenyani J, Harman V, Beynon RJ and Jones AR. A software toolkit and interface for performing stable isotope labelling and top3 quantification using Progenesis LC-MS. OMICS 2012 16(9): 489-495. [Abstract]
- Sanchez-Mazas A, Vidan-Jeras B, Nunes JM, Fischer G, Little AM, Bekmane U, Buhler S, Buus S, Claas F, Dormoy A, Dubois V, Eberhard HP, Eglite E, Gonzalez-Galarza F , Grubic Z, Ivanova M, Lie B, Ligeiro D, Lokki ML, Maldonado-Torres H, Marsh SGE, Martins da Silva B, Martorell J, Mendonça D, Middleton D, Muller C, Papasteriades C, Poli F, Riccio ME, Spyropoulou Vlachou M, Sulcebe C, Tonks S, Toungouz-Nevessignsky M, Vangenot C, van Walraven AM and Tiercy JM. Strategies to work with HLA data in human populations for histocompatibility, clinical transplantation, epidemiology and population genetics: HLA-NET methodological recommendations International Journal of Immunogenetics 2012 39(6): 459-476. [Abstract]
- Alfirevic A, Gonzalez-Galarza F , Bell C, Martinsson K, Platt V, Bretland G, Evely J, Lichtenfels M, Cederbrant K, French N, Nasibitt D, Park K, Jones AR, Pirmohamed M. In silico analysis of HLA associations with drug-induced liver injury: use of a HLA-genotyped DNA archive from healthy volunteers Genome Medicine 2012 4:51. [Full Text - Free Access]
2011
- Gonzalez-Galarza FF, Christmas S, Middleton D and Jones AR. Allele frequency net: a database and online repository for immune gene frequencies in worldwide populations Nucleic Acid Research 2011 39:D913-D919. [Full Text - Free Access] (Featured article)
2010
- Middleton D, Gonzalez F. Immunogenetic Databases. In: Mehra N, eds. The HLA complex in Biology and Medicine: A resource book. New Delhi: Jaypee 2010, 119-134. [Book review]
- Middleton D, Gonzalez-Galarza F, Meenagh A, Gourraud PA. Diversity of KIR genes, alleles and haplotypes In: J. Zimmer eds. Natural Killer Cells: At the Forefront of Modern Immunology. Berlin: Springer-Verlag 2010; 63-91.
2009
- Middleton D, Gonzalez F. The extensive polymorphism of KIR genes. Immunology 2009 129:8-19. [Abstract]
- Middleton D, Gonzalez F, Fernandez-Vina M, et al. A bioinformatic approach to ascertaining the rarity of HLA alleles. Tissue antigens 2009 74:480-485. [Abstract]