large number of non-redundant
from the sand fly Lutzomyia longipalpis have been
sequence at the Sanger Centre as a gene discovery project. We
have developed a genome wide
microarray and are identifying the candidate genes involved
in the interaction of the sand fly with the parasite. In
addition to our own work this gene discovery program will serve
as a major resource and hopefully stimulate other research in
the field of sand fly/Leishmania interactions.
The sequence data can be
accessed and BLAST searched from the
longipalpis pages at the Sanger Institute.
We are also directly involved in a
full genome sequencing programme for Phlebotomine sand flies. Two species of
sand fly were selected for sequencing; one 'Old World' species, Phlebotomus
papatasi that transmits Leishmania major and our 'New World' species
Lutzomyia longipalpis. BAC end sequencing for both species has been
completed and we are now entering the second phase of the sequencing project.